Mitosis sans Mitosis: The Mitotic Oscillator in Differentiation
نویسندگان
چکیده
منابع مشابه
Mitosis sans Mitosis: The Mitotic Oscillator in Differentiation.
Differentiation and proliferation are usually considered to be antagonistic partners in development. However, in a recent issue of Science, Al Jord et al. (2017) show that key regulators of the mitotic cycle are redeployed in differentiating multiciliated cells to promote ciliogenesis without mitotic progression.
متن کاملRomancing mitosis and the mitotic apparatus
One of the earliest lessons students learn in biology is the process of mitosis and how cells divide to produce daughter cells. Although first described more than a century ago by early investigators such as E. B. Wilson, many aspects of mitosis and cell division remain the subject of considerable research today. My personal investigations and research contributions to the study of mitosis were...
متن کاملMitosis in Chlamydomonas Reinhardtii Basal Bodies and the Mitotic Apparatus
Cell division in Chlamydomonas reinhardtii was described by Johnson and Porter (1968). In their paper, they state (p. 409): ". .. they (referring to basal bodies) are not found at the poles of the mitotic apparatus as are the centrioles of animal cells and certain plant cells" (present author's
متن کاملMcl-1 dynamics influence mitotic slippage and death in mitosis
Microtubule-binding drugs such as taxol are frontline treatments for a variety of cancers but exactly how they yield patient benefit is unclear. In cell culture, inhibiting microtubule dynamics prevents spindle assembly, leading to mitotic arrest followed by either apoptosis in mitosis or slippage, whereby a cell returns to interphase without dividing. Myeloid cell leukaemia-1 (Mcl-1), a pro-su...
متن کاملThe Aspergillus nidulans bimE (blocked-in-mitosis) gene encodes multiple cell cycle functions involved in mitotic checkpoint control and mitosis.
The bimE (blocked-in-mitosis) gene appears to function as a negative mitotic regulator because the recessive bimE7 mutation can override certain interphase-arresting treatments and mutations, causing abnormal induction of mitosis. We have further investigated the role of bimE in cell cycle checkpoint control by: (1) coordinately measuring mitotic induction and DNA content of bimE7 mutant cells;...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Developmental Cell
سال: 2017
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2017.11.001